[Campbell Biology P.275] Which of the following sequences correctly describes the events in ... | Practice Question

Which of the following sequences correctly describes the events in the nuclear response to a growth factor signal, as illustrated in Figure 11.15 and described in the text?

  • A: Growth factor binding → Phosphorylation cascade → Transcription factor enters nucleus → Gene transcription → mRNA directs protein synthesis
  • B: Transcription factor enters nucleus → Growth factor binding → Phosphorylation cascade → Gene transcription → mRNA directs protein synthesis
  • C: Phosphorylation cascade → Growth factor binding → Transcription factor enters nucleus → mRNA directs protein synthesis → Gene transcription
  • D: Gene transcription → Growth factor binding → Phosphorylation cascade → Transcription factor enters nucleus → mRNA directs protein synthesis

Explanation

Figure 11.15 illustrates and the text describes the sequence: An initial signaling molecule growth factor binds to a receptor, triggering a phosphorylation cascade. Once activated, the last kinase in the cascade enters the nucleus and activates a transcription factor. This transcription factor stimulates the transcription of a specific gene. The resulting mRNAs then direct the synthesis of a particular protein in the cytoplasm.