[Campbell Biology P.358] The Philadelphia chromosome, associated with chronic myelogenous le... | Practice Question

The Philadelphia chromosome, associated with chronic myelogenous leukemia CML , is an example of which type of chromosomal alteration?

  • A: Deletion
  • B: Inversion
  • C: Translocation
  • D: Nondisjunction

Explanation

Figure 15.16 and the accompanying text clearly describe the formation of the Philadelphia chromosome as a reciprocal translocation, where a large portion of chromosome 22 is exchanged with a small fragment from chromosome 9.