[Campbell Biology P.1045] Conn's syndrome is a condition caused by tumors of the adrenal cort... | Practice Question

Conn's syndrome is a condition caused by tumors of the adrenal cortex that secrete high amounts of aldosterone in an unregulated manner. Based on your understanding of the RAAS, what would be the most expected major symptom of this disorder?

  • A: Low blood pressure and dehydration
  • B: High blood pressure and increased blood volume
  • C: Decreased thirst and increased urine output
  • D: Significant electrolyte imbalance (e.g., very high potassium levels)

Explanation

Aldosterone's primary role in the RAAS is to cause the nephrons' distal tubules and collecting ducts to reabsorb more Na+ and water, thereby increasing blood volume and pressure. In Conn's syndrome, unregulated secretion of high amounts of aldosterone would lead to chronic over-reabsorption of sodium and water, resulting in increased blood volume and, consequently, persistently high blood pressure hypertension .