[Campbell Biology P.1129] Which statement accurately describes the characteristics of metabot... | Practice Question

Which statement accurately describes the characteristics of metabotropic receptors or the specific action of norepinephrine as detailed in the text?

  • A: Compared to ionotropic receptors, metabotropic receptors typically produce postsynaptic potentials with a faster onset and shorter duration.
  • B: Metabotropic receptors directly open or close ion channels upon neurotransmitter binding.
  • C: The binding of norepinephrine to its G protein-coupled receptor results in the direct activation of protein kinase A, which then opens ion channels.
  • D: Activation of a metabotropic receptor for norepinephrine involves a G protein activating adenylyl cyclase, which produces cAMP, leading to protein kinase A activation and subsequent phosphorylation of ion channel proteins.
  • E: Most neurotransmitters bind exclusively to either ionotropic or metabotropic receptors, rarely to both.

Explanation

The text explicitly describes the detailed pathway for norepinephrine's metabotropic receptor: G protein activation, adenylyl cyclase activation, cAMP production, protein kinase A activation, and subsequent phosphorylation of ion channels. Option D accurately reflects this complex, indirect cascade. Other options misrepresent the characteristics of metabotropic receptors or compare them incorrectly to ionotropic receptors.