[Campbell Biology P.484] In 2018, a Chinese researcher sparked controversy by using CRISPR-C... | Practice Question

In 2018, a Chinese researcher sparked controversy by using CRISPR-Cas9 to edit genes in human embryos that resulted in live births. Which of the following statements accurately describes aspects of this case or the broader ethical considerations surrounding germ-line editing mentioned in the text?

  • A: The researcher edited the CCR5 gene to confer resistance against HIV, but this act was widely condemned by the biological community.
  • B: The primary goal of editing the CCR5 gene was to cure sickle-cell disease in the embryos, a commonly accepted application of CRISPR technology.
  • C: The text states that biologists generally agree that germ-line cells should be altered to correct defects for future generations.
  • D: The World Health Organization (WHO) supported the Chinese researcher's work as a breakthrough in gene therapy.

Explanation

The text clearly states that the Chinese researcher edited the CCR5 gene to prevent HIV infection in the twins, and this act was 'roundly condemned as highly unethical by the biological community.' The World Health Organization later proposed establishing a registry to monitor such research, not endorsing it. The consensus among biologists was to 'strongly discourage' experimental work on human eggs or embryos for germ-line editing.