[Campbell Biology P.420] A research team wants to activate a gene that is currently silenced... | Practice Question

A research team wants to activate a gene that is currently silenced in a specific cell type. Based on the provided text, which of the following strategies would most likely lead to the activation of this gene?

  • A: Introducing enzymes that add methyl groups to the histones associated with the gene.
  • B: Enhancing the activity of enzymes that remove methyl groups from the DNA region of the gene.
  • C: Increasing the density of nucleosomes along the gene's promoter.
  • D: Inducing the formation of heterochromatin in the region containing the gene.

Explanation

The text states that 'Removal of the extra methyl groups can turn on some of these genes' regarding DNA methylation. Therefore, enhancing the removal of methyl groups from the DNA region of the silenced gene would be a likely strategy for activation.